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Effect of CT vs. LTIIb on cAMP-dependent Cl− Secretion in Human Intestinal T84 Cells
| Purified native toxin | LAG | dlsc/dt | Peak Isc | |||||
|---|---|---|---|---|---|---|---|---|
| min | μA/cm/min | μA/cm2 | ||||||
| CT | 20 nM | 26 ± 1.3 | 1.2 ± 0.2 | 59 ± 5 | ||||
| n = 9 | ||||||||
| LTIIb | 20 nM | >128* | Not Present | 3.9 ± 0.2* | ||||
| n = 12 | ||||||||
Values are means ± SE.
Peak Isc was obtained at 120 min. ANOVA, P = 0.0001.
