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. 1998 Jun 15;141(6):1349–1356. doi: 10.1083/jcb.141.6.1349

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Activation of PKC disrupts A band assembly. (A) Phorbol 12-myristate, 13-acetate (PMA; 10 nM), a potent activator of PKC, disrupts myofibrillogenesis in the same manner as MLCK inhibitors. Myosin is diffusely distributed throughout these cells, with dense punctate staining located centrally. (B) Co-application of the PKC inhibitor Bis I (100 nM) blocks the action of PMA. Myofibril and sarcomeric structure are normal. (C) PMA application from 6 to 24 h, but not 24 to 48 h, disrupts A band assembly and is rescued by Bis I. Bars, 20 μm.

Activation of PKC disrupts A band assembly. (A) Phorbol 12-myristate, 13-acetate (PMA; 10 nM), a potent activator of PKC, disrupts myofibrillogenesis in the same manner as MLCK inhibitors. Myosin is diffusely distributed throughout these cells, with dense punctate staining located centrally. (B) Co-application of the PKC inhibitor Bis I (100 nM) blocks the action of PMA. Myofibril and sarcomeric structure are normal. (C) PMA application from 6 to 24 h, but not 24 to 48 h, disrupts A band assembly and is rescued by Bis I. Bars, 20 μm.