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. 1998 Jun 15;141(6):1415–1422. doi: 10.1083/jcb.141.6.1415

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Primary structure of BRUCE predicted from the cDNA sequence. (Sequence data are available from GenBank/EMBL/ DDBJ under accession number Y17267.) The NH₂-terminally positioned single BIR repeat and the UBC domain close to the COOH terminus are highlighted. The position of the presumed active-site cysteine residue required for thioester formation with ubiquitin is marked within the UBC domain. The presumed initiator methionine residue was deducted from the position of the first ATG codon found in the cDNA sequence. A schematic representation of the domain structure of BRUCE is shown at the bottom.