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. 1998 Oct 5;143(1):95–106. doi: 10.1083/jcb.143.1.95

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Comparison of the polarized asymmetric distribution of the protein complex of aPKC and PAR-3/ASIP between the C. elegans one-cell embryo and differentiated mammalian epithelial cells. In the C. elegans one-cell embryo, PAR-3 localizes at the anterior periphery with aPKC and determines the distribution of PAR-1, whereas PAR-1 localizes at the posterior periphery in a reciprocal manner. In mammalian epithelial cells, ASIP and PKCλ colocalize at tight junctions, whereas EMK (m-PAR-1) localizes in the lateral domain.