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. 1998 Aug 24;142(4):989–1000. doi: 10.1083/jcb.142.4.989

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(a) A model of the compartmentalized structure of the plasma membrane with regard to translational diffusion of band 3. A band 3 molecule undergoes almost free diffusion within a compartment (slowed only by the presence of other membrane proteins). It sometimes hops from one compartment to an adjacent compartment, and the long-range diffusion of band 3 occurs as a result of successive intercompartmental hops. (b) Membrane-skeleton fence model. In this figure, the plasma membrane is viewed from inside the cell. The spectrin network is in close proximity to the cytoplasmic surface of the plasma membrane. The cytoplasmic domain of band 3 collides with the membrane skeleton and cannot readily move to an adjacent compartment.