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. 1999 Jan 25;144(2):339–349. doi: 10.1083/jcb.144.2.339

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Ig domains 1 and 3 of neurolin contribute to axon fasciculation in vitro. When growth cones elongating on polylysine meet another axon, 47.9% of the growth cones fasciculate with the other axon in control cultures. In the presence of mAb N850 (against Ig domain 1) 36.3% of the growth cones fasciculate with another axon, and 33.9% do so in the presence of mAb N100 (against Ig domain 3). Similar values (32.5%) were obtained in an earlier study (Ott et al., 1998) with neurolin Fabs (shaded bars). mAb N518 (against Ig domain 2) does not affect the level of fasciculation (48.8%).