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. 1999 Jan 25;144(2):305–313. doi: 10.1083/jcb.144.2.305

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Time lapse images of control NRK cells and cells microinjected with C3 transferase during prometaphase or metaphase. Approximate time in minutes relative to anaphase onset is located in the upper right corner. Control cells (a–e) developed a narrow cleavage furrow along the equatorial plane (c–e). Cells microinjected with C3 underwent immediate spreading in all directions (f and g, k and l; f and k were recorded immediately after microinjection). Ingressions were poorly regulated and initiated at several points around the cell after anaphase onset. An elongated cleavage furrow (j, arrowhead) formed as a result of the broad ingression that developed between separating chromosomes. Another cell initiated an ingression before anaphase onset (l), but did not complete cleavage between the sets of chromosomes. Ectopic furrows were common in C3-injected cells (i and j and n and o, arrows). Bars, 20 μm.