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. 1999 Feb 22;144(4):777–788. doi: 10.1083/jcb.144.4.777

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Inhibition of LCL binding by piceatannol. Increasing concentration of LY294002 or piceatannol were incubated with LCL for 15 min. Cells were then assessed for adhesion as described above. LY294002 caused visible decreases in LCL spreading at concentrations as low as 2.5 μM (asterisk), and inhibited PI(3)K activity, (inset), but did not block attachment at concentrations below 100 μM. The derived IC₅₀ for piceatannol inhibition of adhesion was ∼5 μM. Inhibition of Syk (> 90%), but not the related src family kinase Lyn (18 ± 11%) was assessed by autokinase activity (inset).