Figure 1.
Nucleotide sequence and derived amino acid sequence of LYVE-1, a novel human HA receptor. A shows the complete nucleotide and derived amino acid sequence for the 2,313-bp LYVE-1 cDNA clone in pBluescript. A cleavable NH2-terminal leader predicted using the −3 +1 rule (56) and a probable transmembrane anchor are underlined. The positions of two putative N-glycosylation sites (N X S/T) are boxed. The sequence predicts a 322–amino acid residue polypeptide with a 26-residue leader peptide, a 21-residue hydrophobic membrane anchor, and a 63-residue cytoplasmic tail. B depicts Kyte-Doolittle (solid line) and Goldman (stippled line) hydropathy plots of the derived amino acid sequence, both of which confirm the position of the predicted hydrophobic transmembrane anchor. These sequence data are available from GenBank under accession number AF118108.