Table II.
Chromosome End-to-End Fusions in Wild-type and mTER−/− Cell Lines as a Function of the Population Doubling
| Cell line and population doubling | Metaphases analyzed | Type of fusion | Fusions per metaphase | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p-arm | q-arm | |||||||||||||
| Type I | Type II | Type III | Type IV | Type V | ||||||||||
| Wt14 | ||||||||||||||
| PD 20 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||
| PD 96 | 25 | 4 | 0 | 0 | 0 | 0.16* | ||||||||
| PD 243 | 26 | 5 | 0 | 0 | 0 | 0 | 0.19 | |||||||
| PD 350 | 25 | 4 | 0 | 1 | 0 | 0 | 0.2 | |||||||
| KO16-G1 | ||||||||||||||
| PD 19 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||
| PD 81 | 26 | 5 | 0 | 33 (0;25) | 1 | 1 | 1.54 | |||||||
| PD 215 | 30 | 6 | 0 | 105 (0;46) | 0 | 1 | 3.73 | |||||||
| PD 322 | 20 | 5 | 18 | 121 (0;38) | 7 | 23 | 8.70 | |||||||
| KO19-G1 | ||||||||||||||
| PD 2 | 15 | 0 | 0 | 1 | 0 | 0 | 0.82 | |||||||
| PD 280 | 15 | 4 | 13 | 56 (2;5) | 2 | 16 | 6.07 | |||||||
| KO2-G2 | ||||||||||||||
| PD 2 | 31 | 4 | 0 | 0 | 1 | 4 | 0.29 | |||||||
| PD 221 | 25 | 4 | 17 (4;1) | 95 (3;2) | 0 | 27 | 5.72 | |||||||
| KO7-G4 | ||||||||||||||
| PD 2 | 25 | 7 | 0 | 0 | 0 | 7 | 0.56 | |||||||
| PD 159 | 20 | 6 | 13 (3;1) | 105 (4;7) | 3 | 8 | 6.75 | |||||||
| KO9-G6 | ||||||||||||||
| PD 2 | 25 | 17 | 24 (24;0) | 1 | 0 | 1 | 1.72 | |||||||
| PD 5 | 31 | 4 | 21 (21;0) | 5 (0;1) | 1 | 0 | 1.00 | |||||||
| PD 12 | 29 | 3 | 27 (27;0) | 19 (0;9) | 0 | 0 | 1.69 | |||||||
| PD 88 | 20 | 0 | 24 (20;0) | 34 (0;3) | 0 | 5 | 3.15 | |||||||
| KO11-G6 | ||||||||||||||
| PD 1 | 11 | 4 | 2 (2;0) | 0 | 1 | 2 | 0.82 | |||||||
| PD 15 | 13 | 4 | 5 (5;0) | 4 | 1 | 3 | 1.31 | |||||||
| PD 53 | 14 | 5 | 9 (9;0) | 70 (10;6) | 4 | 8 | 6.86 | |||||||
| PD 90 | 20 | 2 | 10 (7;1) | 104 (11;10) | 3 | 7 | 6.7 | |||||||
*
One terminal translocation detected after PD 96 and found to be clonal.