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. 1998 Nov 16;143(4):875–885. doi: 10.1083/jcb.143.4.875

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The two nuclear targeting signals of Vpr target the protein to distinct import pathways. (A–F) Import of Vpr(1–71)–βgal, Vpr(73–96)–βgal, and full-length Vpr–βgal with lysate (control) (A, C, and E) or with lysate containing 50 μM unlabeled Vpr(1–71) as a competitor (B, D, and F). (G–L) Import of Vpr(1–71)– βgal, Vpr(73–96)–βgal, and Vpr–βgal with lysate containing unlabeled Vpr(96–73) reverse peptide as a control (G, I, and K) or Vpr(73–96) forward peptide (H, J, and L). Peptides were used at a final concentration of 500 μM.