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. 1998 Nov 16;143(4):1067–1075. doi: 10.1083/jcb.143.4.1067

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Antibody against endogenous α7β1 integrin inhibits laminin-induced AChR clustering. AChR clustering was initiated in RMo rat myotubes with agrin, laminin, or agrin and laminin. Anti-α7 O26 antibody, reactive with the endogenous rat α7 integrin chain, had no effect on agrin-induced clustering (n = 55). The antibody inhibited ∼50% of laminin-induce AChR clustering (n = 103) as well as the enhanced clustering promoted by laminin and agrin (n = 154). n = number of clusters scored in control wells (no antibody). The mean values scored in six samples per condition, ±SE, are given.