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. 1998 Dec 14;143(6):1547–1558. doi: 10.1083/jcb.143.6.1547

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Overexpression of headless Xklp3 inhibits pigment dispersion. Cell nuclei were injected with plasmids pEGFP-C1 (A) or pEGFP-headless Xklp3 (B). Cells were allowed to recover and express exogenous protein for 48 h and then treated with melatonin for 1 h to induce pigment aggregation, followed by 1 h in MSH, to disperse pigment. A cell expressing EGFP (A) dispersed its pigment normally, while a cell expressing the EGFP-headless Xklp3 fusion protein (B) dispersed melanosomes only partially. Bright field and fluorescence images of cells were overlaid to show pigment distribution in cells expressing EGFP-tagged proteins. Bar, 20 μm.