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. 1998 Dec 14;143(6):1617–1634. doi: 10.1083/jcb.143.6.1617

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(a) EcoRI restriction analysis of PCR products from an inner fragment of the cdc15-lyt1 allele (lanes 1, 2, and 3 represent three different amplificates) and the CDC15 gene (lane 4), showing the disappearance of an EcoRI cleavage site in the mutant allele. (b) Sequence comparison of the CDC15-encoded peptide in the area where the lyt1 mutation maps from the mutant, the wild-type, and the putative homologue in the fission yeast S. pombe (Sp), cdc7. Underline, EcoRI site in the corresponding DNA sequence; boldface; residues affected by the mutation; asterisks, conserved residues; dots, structurally similar residues in the S. cerevisiae and S. pombe sequences.