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. 1998 Jun 29;141(7):1659–1673. doi: 10.1083/jcb.141.7.1659

Figure 13.

Figure 13

Effect of anti-VEGF antibody on FGF-2–induced angiogenesis. Hydron pellets containing 50 ng of rFGF-2 with or without 1 μg of anti-VEGF monoclonal antibody were implanted in the cornea of both eyes of Swiss Webster mice as described in Materials and Methods. Each group consisted of six animals. The corneas were photographed by slit-lamp biomicroscopy on day 5 after implantation of the pellet. FGF-2 pellet: eyes that received corneal implantation of pellets containing FGF-2 alone. FGF-2/ VEGF IgG pellet: eyes that received corneal implantation of pellets containing FGF-2 and antibody to VEGF. The eyes that received corneal implants of pellets containing FGF-2 and VEGF antibody have fewer and thinner corneal limbic capillaries than eyes that received corneal implants of pellets containing FGF-2 alone.