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. 1998 Jun 29;141(7):1659–1673. doi: 10.1083/jcb.141.7.1659

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Expression of VEGF mRNA by the endothelial cells of branching capillaries. Photomicrographs taken in a through-focus series (1-μm steps) of a 30 μm-thick section of mouse cornea hybridized in situ with a DIG-labeled antisense riboprobe to VEGF. A hydron pellet containing 50 ng of rFGF-2 was implanted in the cornea 5 d before sectioning. Implantation of the pellet in the cornea, preparation of the probes, and in situ hybridization were carried out as described in Materials and Methods. Contrast was enhanced by computer to increase the appearance of the reaction product. Arrowheads, the wall of a capillary branching out of a larger vessel (top left corner of each panel). A homogenous hybridization signal is associated with the endothelium of the branching capillary (arrowheads, panels 2–5) but not with the endothelium of the larger vessel. In panels 1 and 5 the capillary is below and above the focus plane, respectively.