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. 1998 Jun 29;141(7):1489–1502. doi: 10.1083/jcb.141.7.1489

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Ultrathin cryosections of HepG2 cells showing the subcellular distribution of human sec22b (hsec22b). (A and C) Double immunogold labeling for hsec22b (15 nm gold) and COPII (10 nm gold). hsec22b colocalizes to a high extent with COPII to VTC membranes. Label in the Golgi (G), if detectable, is restricted to the cis-most cisterna (arrow in C). Note that the membrane buds evolving from the ER (large arrowhead in A) are coated with COPII. (B) Double immunogold labeling for hsec22b (15 nm gold) and COPI (10 nm gold). COPI-coated membranes (small arrowheads) show a much more widespread distribution than hsec22b-positive membranes. Bars, 200 nm.