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Effects of β3 cytoplasmic tail mutations on PAC1 binding caused by receptor clustering and affinity modulation. CHO cells were transiently transfected with the indicated αIIb and β3 subunits. 48 h later, they were incubated for 30 min with PAC1 along with AP1510 and/or 150 μg/ml anti–LIBS6 Fab, and specific PAC1 binding was quantitated by flow cytometry. Note the almost 10-fold difference in scales of the y axes. Data represent the means ± SEM of three experiments.
