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. 1998 Jul 13;142(1):1–11. doi: 10.1083/jcb.142.1.1

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Sequence comparison of Bub3 homologues. Schematic representation of hBub3 showing the location of the four WD repeats and an alignment of the Bub3 and Rae1 homologues from human (h), S. cerevisiae (Sc) and S. pombe (Sp). The sequences are arranged such that the WD repeats are aligned with each other and with the WD repeat consensus (Dalrymple et al., 1989). The positions of WD repeat consensus residues are indicated with a +. Note the conserved glycine in the Rae1 homologues, marked with an *, that is not conserved in the Bub3 homologues. The rae1-1 loss of function allele in S. pombe results from a substitution of this glycine with a glutamic acid (Brown et al., 1995). The four amino acids deleted to generate the hBub3ΔVAVE mutant are identified with a solid bar.