Table II.

Effect of PKC β_II Transgene Expression on Proliferative Parameters in the Colon

		Control		Transgenic		P value
Labeling index
Entire crypt		21.4 ± 0.9		28.3 ± 0.2		0.0001
Top 1/3 crypt		0.2 ± 0.2		0 ± 0		NS
Middle 1/3 crypt		13.8 ± 2.5		17.8 ± 1.0		NS
Bottom 1/3 crypt		50.0 ± 2.7		67.5 ± 1.4		0.0005
Proliferative zone
Entire crypt column		37.1 ± 2.5		41.4 ± 1.1		NS

Results are shown as means ± SEM on a sample size of four to five mice/group. NS, not significantly different, (P > 0.05).