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. Author manuscript; available in PMC: 2008 Nov 1.

Published in final edited form as: Leuk Res. 2007 Apr 2;31(11):1553–1563. doi: 10.1016/j.leukres.2007.02.017

Effect of AMD3100 on adhesion of CD34+ cells and AML blasts to marrow endothelial monolayers. AMD3100 at concentrations up to 1.0 mg/ml did not significantly affect adhesion of AML cells to HUVECs (A). This was also the case in the presence of Interleukin-1 and Tumor necrosis factor-alpha, both of which upmodulate stromal cell expression of VLA-4 (CD49d) and other integrins. Likewise, adhesion of normal CD34+ cells was not affected by presence of AMD3100 when BMECs were utilized as the substratum (B). N=3. Data shown is Mean ± SD.

Effect of AMD3100 on adhesion of CD34+ cells and AML blasts to marrow endothelial monolayers. AMD3100 at concentrations up to 1.0 mg/ml did not significantly affect adhesion of AML cells to HUVECs (A). This was also the case in the presence of Interleukin-1 and Tumor necrosis factor-alpha, both of which upmodulate stromal cell expression of VLA-4 (CD49d) and other integrins. Likewise, adhesion of normal CD34+ cells was not affected by presence of AMD3100 when BMECs were utilized as the substratum (B). N=3. Data shown is Mean ± SD.