Figure 4.

P-selectin affects the seeding of intravenously injected tumor cells. Mice were injected with [³H]thymidine-labeled LS180 cells. After 3 hr, tissues were homogenized and proteolyzed, and radioactivity was monitored, as described under Materials and Methods. To correct for differences in recovery of radioactivity per mouse, the results are shown as the ratios of radioactivity found in various organs relative to that found in the brain (which had 4–7% of the radioactivity in all mice). Residual radioactivity in the circulating blood was similar in both groups. Statistical significance values were generated by using Wilcoxon rank–sum test.