Abstract
Experiments are described on the latency period in sensitization to poison ivy and on the time necessary for the agent to remain in contact with the skin. The chief matter of investigation concerned the manner in which the whole skin becomes sensitive following treatment at a particular site, and especially whether this is effected by way of the epidermis. Two methods were used to interrupt the continuity of the skin, one by cutting through both skin and the underlying thin muscular layer, the other by removing a strip of skin so as to spare the skin muscle. These procedures led to different results when poison ivy extract was applied to the areas thus isolated. In the first case, sensitization was mostly prevented, whereas with the second method generalized hypersensitiveness occurred almost uniformly. An explanation is to be found in the severance of the lymph vessels lying on the surface of the muscular layer, pointing to the necessity of a free lymph passage. On the other hand the experiments prove that general sensitization is not dependent upon maintaining the integrity of the skin around a treated area. An inhibition of sensitization by incisions extending through the panniculus carnosus was seen to some extent in anaphylactic sensitization with protein antigens, namely when sufficiently small amounts were employed.
Full Text
The Full Text of this article is available as a PDF (1.0 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Hudack S. S., McMaster P. D. THE LYMPHATIC PARTICIPATION IN HUMAN CUTANEOUS PHENOMENA : A STUDY OF THE MINUTE LYMPHATICS OF THE LIVING SKIN. J Exp Med. 1933 Apr 30;57(5):751–774. doi: 10.1084/jem.57.5.751. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Joyner A. L., Sabin F. R. ALTERED CUTANEOUS CONDITIONS IN THE SKIN OF TUBERCULOUS GUINEA PIGS AS DEMONSTRATED WITH A VITAL DYE. J Exp Med. 1938 Aug 31;68(3):325–334. doi: 10.1084/jem.68.3.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Landsteiner K., Chase M. W. STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : IV. ANAPHYLAXIS INDUCED BY PICRYL CHLORIDE AND 2:4 DINITROCHLOROBENZENE. J Exp Med. 1937 Aug 31;66(3):337–351. doi: 10.1084/jem.66.3.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Landsteiner K., Di Somma A. A. STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : V. SENSITIZATION TO DIAZOMETHANE AND MUSTARD OIL. J Exp Med. 1938 Sep 30;68(4):505–512. doi: 10.1084/jem.68.4.505. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Landsteiner K., Jacobs J. STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : III. ANAPHYLAXIS INDUCED BY ARSPHENAMINE. J Exp Med. 1936 Oct 31;64(5):717–721. doi: 10.1084/jem.64.5.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Landsteiner K., Jacobs J. STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS. II. J Exp Med. 1936 Sep 30;64(4):625–639. doi: 10.1084/jem.64.4.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Landsteiner K., Jacobs J. STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS. J Exp Med. 1935 Apr 30;61(5):643–656. doi: 10.1084/jem.61.5.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McMaster P. D., Hudack S. S. THE FORMATION OF AGGLUTININS WITHIN LYMPH NODES. J Exp Med. 1935 May 31;61(6):783–805. doi: 10.1084/jem.61.6.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McMaster P. D., Kidd J. G. LYMPH NODES AS A SOURCE OF NEUTRALIZING PRINCIPLE FOR VACCINIA. J Exp Med. 1937 Jun 30;66(1):73–100. doi: 10.1084/jem.66.1.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rous P. THE RELATIVE REACTION WITHIN LIVING MAMMALIAN TISSUES : VI. FACTORS DETERMINING THE REACTION OF SKIN GRAFTS; A STUDY BY THE INDICATOR METHOD OF CONDITIONS WITHIN AN ISCHEMIC TISSUE. J Exp Med. 1926 Nov 30;44(6):815–834. doi: 10.1084/jem.44.6.815. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sabin F. R., Joyner A. L. TUBERCULAR ALLERGY WITHOUT INFECTION. J Exp Med. 1938 Oct 31;68(5):659–676. doi: 10.1084/jem.68.5.659. [DOI] [PMC free article] [PubMed] [Google Scholar]