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. 1983 Jun;90(3):351–359. doi: 10.1017/s0022172400028989

A comparison of live and inactivated influenza A (H1N1) virus vaccines. 1. Short-term immunity.

A Clark, C W Potter, R Jennings, J P Nicholl, A F Langrick, G C Schild, J M Wood, D A Tyrrell
PMCID: PMC2134273  PMID: 6863909

Abstract

Groups of volunteers were immunized subcutaneously with one of three inactivated influenza virus A/USSR/77 (H1N1) vaccine preparations; a whole virus vaccine, a surface-antigen subunit adsorbed vaccine, or an aqueous surface-antigen subunit vaccine. The reactions to immunization were recorded, and the antibody response was measured 1 month later. A fourth group of volunteers were inoculated intranasally with live attentuated A/USSR/77 (H1N1) influenza virus; the reactions and antibody response of these volunteers were also measured. One month after immunization, the incidence of infection by challenge with homologous live attentuated virus was determined for all groups of volunteers. The results showed that all four vaccines used were relatively non-reactogenic, and that inactivated vaccines induced higher titres of serum antibody than the live attenuated vaccine. All the vaccines induced significant protection against challenge virus infection which was directly related to the level of serum HI antibody response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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