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. 1997 Feb 10;136(3):621–631. doi: 10.1083/jcb.136.3.621

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Distribution of Ank1 proteins in skeletal muscle. Cross sections of adult rat diaphragm were labeled with the polyclonal p65 antibody to the spectrin-binding domain of Ank1 (A) and the p6 antibody to the small ankyrins (C). The sections were doublelabeled with monoclonal antibodies to syntrophin to mark the sarcolemma (B and D). The bound antibodies were detected with rhodamine-conjugated goat anti–rabbit IgG and FITC-conjugated goat anti–mouse IgG secondary antibodies. The results show that the 210-kD (and perhaps the 70-kD) ankyrin of skeletal muscle is distributed at the sarcolemma and nuclei while the small ankyrins are inside the muscle fibers. Bars, 20 μm.