Fig 10.

Relationship between the degree of renal failure and the lymphocyte heat shock response in diabetic nephropathic patients. Lymphocyte samples from 21 patients with nephropathy secondary to type 2 diabetes and 16 age-matched controls were assayed for heme oxygenase-1 (HO-1, panel A) and heat shock protein70 (Hsp70, panel B) as described in Figures 4 and 6, respectively. Heme oxygenase-1 and Hsp70 levels then were plotted against the 24-h proteinuria values of each subject. Proteinuria is a reliable clinical index of renal failure. Significant linear positive correlations have been found. Heme oxygenase-1 and Hsp70 levels are expressed as densitometric units (D.U.), whereas urinary protein is in mg/24 h. Control subjects had urinary proteins ranging from 30 to 120 mg/24 h