Figure 5.

TEM analyses of hepatic cells differentiating in vitro. The selected views were obtained in H/O cultures of 11-dpc c-Kit^low(CD45/TER119)^– R4 cells, (b and e) except those that were from R3 + R4 cell cultures. (a and b) Cytoplasms enriched in organelles and deposits such as mitochondria, smooth endoplasmic reticulum, lipidic, and glycogen accumuli. (c) Ferritin deposits. (d and e) Examples of a small bile duct and a biliary canaliculus with microvilli and closing tight junctions. (f) Endosome linked to intermediate filaments. Er, endoplasmic reticulum; m, mitochondria; g, glycogen deposits; lip, lipid vacuoles; fe, ferritin; v, microvilli; j, tight junction. The original magnifications were between ×8,000 and ×12,000.