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Energy landscape of Tf-TfR complex. The dissociation of holo-Tf-TfR complex at pH 7.4 involves overcoming two activation barriers (solid line), whereas the unbinding pathway of apo-Tf-TfR complex at pH 5.3 has only one barrier (dashed line). Positions of the barriers and energy differences between them were obtained from the Bell model parameters given in Table 1. Estimations of 
were calculated from the dissociation constants (see text for details).
