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. Author manuscript; available in PMC: 2007 Dec 12.

Published in final edited form as: Tetrahedron Lett. 2005 Jul 11;46(28):4821–4823. doi: 10.1016/j.tetlet.2005.04.143

Scheme 1 — Reagents and conditions: (a) (1) NaNO₂, H₂SO₄, CuCN, NaCN, (2) HCl, SnCl₂·2H₂O, EtOH; (b) (1) methacryloyl chloride, NaOH, acetone, (2) NBS, DMF, (3) HBr; (c) SOCl₂, THF; (d) K₂CO₃, acetone; (e) K₂CO₃, 2-propanol; (f) Pd(PPh₃)₄, hexamethyl ditin, toluene; (g) NaI (Na¹²⁵I), chloramine T, MeOH; (h) acetyl chloride, absolute EtOH; (i) chloroform, thiophosgene, NaHCO₃; *I = I or ¹²⁵I.