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. 2007 Dec 14;3(12):e191. doi: 10.1371/journal.ppat.0030191

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A given dose of virus was used to inoculate intracerebrally (IC) or intraperitoneally (IP) groups of PVR-Tg mice expressing the human poliovirus receptor (8–10 animals per virus). Animals were checked daily for 14 d following inoculation for paralysis and death. Percentages of affected mice following inoculation of viruses MAD 04 to MAD 07, MAD 29, and of a positive neurovirulent control virus S2/4568 are given. Strain S2/4568 was used only for IP inoculation. IP or IC inoculation of the vaccine strain Sabin 2 did not induce disease in animals.