Figure 3. Timing of the Gene Losses in the Human Lineage Since the Common Ancestor of Euarchontoglires, Estimated Based on Shared Mutation Analysis.

Branch intervals enclosing the earliest ORF-disrupting mutations shared between human and other mammals are illustrated on the human lineage of a mammalian species tree. Genes are represented by numbers, which correspond to their row numbers in Tables 1 and 2. Marks on the rhesus lineage represent independent ORF-disrupting mutations that are not shared with the ones in the human lineage. Approximate time when the species diverged from the human lineage is shown in Mya. Species with complete genome sequences are enclosed by rectangles, while others only have trace sequences available for analysis. Orang.: orangutan; Marm.: marmoset; T.shrew: tree shrew.