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. Author manuscript; available in PMC: 2008 Nov 1.
Published in final edited form as: Trends Cardiovasc Med. 2007 Nov;17(8):258–262. doi: 10.1016/j.tcm.2007.09.002

Figure 2.

Figure 2

The genetic organization of the human Cypher/ZASP gene with the identified mutations shown in different colors to illustrate diseases associated with each mutation. The PDZ domain, ZM motifs, and LIM domains are highlighted. Transcriptional start (ATG) and stop (TAG and TAA) codons are also delineated. INLVM: isolated non-compaction of the left ventricular myocardium; DCM: dilated cardiomyopathy; HCM, hypertrophic cardiomyopathy. Exon 9 is the last exon of short Cypher isoforms, while exon 16 is the last exon of large Cypher isoforms.