Table 1.

Summary of sequence properties for 2,820 aligned orthologous human–rodent mRNAs and protein sequences

Property	Rat–human			Mouse–human			Mouse–rat
	Mean (SD)	Median	Range	Mean (SD)	Median	Range	Mean (SD)	Median	Range
5′ UTR
% Identity	68.4 (13.0)	66.7	36.6–100	69.7 (12.9)	67	40.7–100	84.5 (12.9)	87.1	41.7–100
Aligned length, bp	98 (96)	65	20–879	124 (129)	94	20–1521	97 (99)	64	20–752
Mutation distance K	0.486 (0.260)	0.453	0.00–1.595	0.493 (0.273)	0.458	0.00–1.559	0.212 (0.224)	0.142	0.00–1.237
Mutation rate (×10−9)	2.9 (1.6)	2.8	0.00–10.0	2.75 (1.7)	2.86	0.0–9.7	67 (4.7)	7.5	0.0–41.0
CDS
% Identity (protein)	88.0 (11.8)	91.3	40.3–100	86.4 (12.3)	89	41.1–100	94.5 (6.3)	96.6	62.4–100
% Identity (DNA)	85.9 (6.0)	87	58.3–98.4	85.2 (6.5)	86.2	60.7–97.6	93.8 (3.2)	94.3	75.4–98.9
Aligned length, bp	1400 (1054)	1194	78–9780	1425 (1164)	1175	135–13635	1293 (951)	1104	154–8250
Syn. distance Ks	0.460 (0.145)	0.446	0.057–1.646	0.468 (0.169)	0.46	0.074–1.99	0.166 (0.061)	0.163	0.01–0.61
Syn. rate (×10−9)	2.86 (0.91)	2.79	0.35–10.0	2.91 (1.01)	2.87	0.46–12.4	5.53 (2.07)	5.54	0.34–20.3
Nonsyn. distance Ka	0.078 (0.095)	0.051	0.00–0.609	0.090 (0.102)	0.066	0.00–0.696	0.031 (0.040)	0.018	0.00–0.25
Nonsyn. rate (×10−9)	0.49 (0.6)	0.32	0.00–3.81	0.55 (0.63)	0.39	0.00–3.81	1.05 (1.46)	0.63	0.00–13.5
3′ UTR
% Identity	70.1 (11.4)	68.6	40.0–98.4	71.0 (12.2)	69.4	31.1–100	86.3 (8.9)	87.7	48.8–100
Aligned length, bp	388 (380)	264	40–3164	416 (432)	263	40–3478	392 (391)	235	43–2996
Mutation distance K	0.435 (0.212)	0.416	0.016–1.230	0.447 (0.225)	0.425	0.00–1.424	0.164 (0.152)	0.136	0.00–1.179
Mutation rate (×10−9)	2.6 (1.3)	2.6	0.1–7.7	2.6 (1.4)	2.7	0.0–8.9	4.95 (5.1)	4.5	0.0–39.3