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Fractional excretion of Na+. At day 8 after birth, the fractional excretion of Na+ of untreated (black columns) and amiloride-treated (white columns) MR −/−, heterozygous (+/−), and wild-type (+/+) animals was determined. Values of MR-deficient (−/−) or heterozygous (+/−) animals that are statistically different from wild-type (+/+) are marked with asterisks. ∗, P < 0.05; ∗∗, P < 0.005 (see also Table 2).
