Table 1.

Weight, hematocrit, and analysis of the RAAS

	+/+	+/−	−/−
Measurement
1. Weight, g	5.2 ± 0.2	5.1  ± 0.1	3.3  ± 0.1**
	(n = 22)	(n = 40)	(n = 22)
2. Hematocrit, %	32.3 ± 0.7	33.3  ± 0.4	43.5  ± 0.7**
	(n = 22)	(n = 40)	(n = 22)
3(a). Plasma renin concentration, ng ANGI/ml⋅h, day 8	577 ± 95	2022  ± 290**	253201  ± 24917**
	(n = 9)	(n = 22)	(n = 18)
3(b). Plasma renin concentration, ng ANGI/ml⋅h, day 4	697 ± 209	667  ± 79	5636  ± 1567*
	(n = 6)	(n = 16)	(n = 9)
3(c). Plasma renin concentration, ng ANGI/ml⋅h, day 0	295 ± 39	335  ± 48	328  ± 43
	(n = 6)	(n = 21)	(n = 6)
4. Plasma angiotensin II, pg/ml	69 ± 14	222  ± 27**	3546  ± 401**
	(n = 3)	(n = 6)	(n = 9)
5. Plasma aldosterone, pg/ml	377 ± 69	1132  ± 140**	24510  ± 1572**
	(n = 11)	(n = 10)	(n = 8)

All measurements were performed on 8-day-old mice, except 3(b) and 3(c). Results shown are mean ± SEM. Values of MR-deficient (−/−) or heterozygous (+/−) animals that are statistically different from wildtype (+/+) are marked with asterisks. ANGI, angiotensin I. 

^*P < 0.05 (Student’s t test, unpaired). 

^**P < 0.005 (Student’s t test, unpaired).