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Amphetamine-induced Fos expression is enhanced in core and shell subregions after repeated amphetamine administration in the locomotor activity chamber. Graphs indicate the number of Fos-IR nuclei in core (A) and shell (B) 2 mm anterior to Bregma. Values represent mean±SEM (n=6–8 per group). * indicates significantly more amphetamine-induced Fos-IR for each challenge dose after repeated administration of amphetamine versus saline.
