Figure 1.

Southern blot analysis of genomic DNA from wild type, p^6H/p^6H, p^bs/p^bs, p^cp/p^cp, and p^25H/p^25H homozygous mice digested with HindIII and hybridized with the BS2c probe (corresponding to nucleotides 12661–14606 of the final rjs cDNA contig that includes part of RLDc and all of the HECT domain). Marker lane contains size markers with position in kb indicated at left. Note deletion of all bands except lowest molecular weight band in p^6H/p^6H DNA.