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. 1997 Jun 2;137(5):1137–1147. doi: 10.1083/jcb.137.5.1137

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Transmission electron microscopy of LC migrating in skin organ cultures. Skin organ cultures were performed as described in Materials and Methods. 4-mm skin punch biopsies were cultured in Nunc filters for 12 h and examined by electron microscopy. (A) After 12 h of culture, an LC with a multilobulated nucleus is migrating across the dermo-epidermal junction (arrow). (B) High magnification of the same LC shown in the box in A. (Inset) Magnified from the area delineated by the box: Birbeck granules. (C) LC form cordlike structures within dermal lymphatic vessels after 24 h of culture. (D) High magnification of an LC in lymphatic vessel identified by a single layer of endothelial cells with protruding nuclei (arrow). (Inset) Magnified from the area delineated by the box: Birbeck granule remnants. Bars: (A and C) 6 μm; (B and D) 0.8 μm.