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. 1997 Jun 2;137(5):1137–1147. doi: 10.1083/jcb.137.5.1137

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The binding of LC or DC to paracortical lymph node areas is inhibited by antibodies to CD44. Microbead-purified fresh LC (A), LC cultivated for 48 h (B and E), or cytokine-activated DC (C, D, and F) were layered on frozen sections of lymph node. LC and DC adhered preferentially to the paracortical T cell areas, with enhanced adhesion upon activation by culture, and not to the central B cell follicles. The binding was also assayed in the presence of antibodies (quantified in E and F; *statistically significant at P < 0.05, one way ANOVA, Dunnett's test). Representative for four independent experiments. Bar: (A–C) 10 μm; (D) 100 μm.

The binding of LC or DC to paracortical lymph node areas is inhibited by antibodies to CD44. Microbead-purified fresh LC (A), LC cultivated for 48 h (B and E), or cytokine-activated DC (C, D, and F) were layered on frozen sections of lymph node. LC and DC adhered preferentially to the paracortical T cell areas, with enhanced adhesion upon activation by culture, and not to the central B cell follicles. The binding was also assayed in the presence of antibodies (quantified in E and F; *statistically significant at P < 0.05, one way ANOVA, Dunnett's test). Representative for four independent experiments. Bar: (A–C) 10 μm; (D) 100 μm.