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. 1997 Jun 2;137(5):989–1000. doi: 10.1083/jcb.137.5.989

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Expression of HA-Nup84Δ607 in BHK cells. HA-Nup84Δ607, detected with 12CA5, localizes exclusively to the cytoplasm regardless of expression level (A). No association with the nuclear envelope is evident. In B–G, the effects of HA-Nup84Δ607 expression (B, D, and F) on endogenous CAN/Nup214 localization (C, E, and G), detected with guinea pig anti–CAN/Nup214 are shown. It is apparent that HA-Nup84Δ607 overexpression causes mislocalization of some of the endogenous CAN/Nup214 to the cytoplasm. For comparison, the effects of full-length HA-Nup84 (H) are also shown. In this case there is no obvious effect on endogenous CAN/Nup214 localization (I). Bars (A and B–I) 10 μm.