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. 1953 Mar 31;97(4):505–509. doi: 10.1084/jem.97.4.505

THE EFFECT OF TEMPERATURE ON THE GROWTH OF VIRUS-INDUCED FROG CARCINOMA

II. THE TEMPERATURE COEFFICIENT OF GROWTH IN VITRO

Balduin Lucké 1, Leonard Berwick 1, Peter Nowell 1
PMCID: PMC2136287  PMID: 13052816

Abstract

The temperature coefficient of van't Hoff, Q 10, for growth of frog carcinoma in vitro over a range of 20–35°C, averages 2.5. This value is closely similar to those obtained for various forms of normal growth. The values of the temperature coefficient slightly but progressively decrease with advancing age of the cancer colonies. A similar relation obtains in many but not in all forms of normal growth. Thus, the law of van't Hoff is found to hold equally for growth of the malignant tissue now under discussion and for normal tissue.

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Selected References

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  1. Ebeling A. H. MEASUREMENT OF THE GROWTH OF TISSUES IN VITRO. J Exp Med. 1921 Aug 31;34(3):231–243. doi: 10.1084/jem.34.3.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. LUCKE B., SCHLUMBERGER H. Induction of metastasis of frog carcinoma by increase of environmental temperature. J Exp Med. 1949 Mar;89(3):269–278. doi: 10.1084/jem.89.3.269. [DOI] [PMC free article] [PubMed] [Google Scholar]

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