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. 1998 Aug 4;95(16):9477–9481. doi: 10.1073/pnas.95.16.9477

Figure 3.

Figure 3

T cell dependence of antibody responses against HBcAg und S2–16. (A) ICR nude mice were immunized twice (interval 13 days) with either HBcAg (black bars) or S2–16 (open bars) particles, and primary IgM and secondary IgG antibody titers against natural HBcAg (left) or preS1 peptide 21–47 (right) were determined by ELISA at the indicated time points. Each bar represents the mean of titers in three animals. Variations were within ±1 dilution step. One of two experiments. (B) CBA (black bars), CBAxid (striped bars), and CD4+ T cell-depleted CBAxid (open bars) mice were immunized twice (interval 13 days) with either HBcAg or S2–16 capsids as indicated, and primary IgM or secondary IgG antibodies to natural HBcAg (left) or preS1 peptide 21–47 (right) were determined by ELISA on the indicated time points. Each bar represents the mean of titers of two to three animals.