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. 1997 Sep 8;138(5):1139–1147. doi: 10.1083/jcb.138.5.1139

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Potential roles for zyxin's nuclear–cytoplasmic shuttling activity. Zyxin's capacity to shuttle between the nucleus and the focal contacts would allow it to convey information between these two cellular locations. Zyxin may play a nuclear role, possibly modulating the transcriptional machinery (a). Zyxin's shuttling activity could serve to sequester a nuclear protein at focal contacts where a particular signal would elicit its release from zyxin (b). Zyxin may act as a chaperone to escort nuclear factors to the cytoplasm and potentially localize them to sites of cell adhesion (c). Lastly, zyxin's nuclear cytoplasmic shuttling activity may be a mechanism to ensure cytoplasmic distribution of this protein after cell division. See text for additional discussion.