Abstract
The earlier observed pronounced hypogammaglobulinemia in germfree rats of different ages has been confirmed. Using an immunologic technique the concentration of immunologic gamma globulins were found to vary between 10 and 15 per cent of the values observed in ordinary rats. Upon contamination of germfree rats with the normal microbial flora a pronounced lag phase was noted before the gamma globulin level became normal. This lag phase was most pronounced in growing rats. Newborn rats seem to start gamma globulin production more rapidly than older germfree rats. The response with regard to gamma globulin production on contamination of germfree rats with different types of bacterial cells through the natural routes is not identical.
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Selected References
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- BASINSKI D. H., BRENNAN M. J., GOODMAN M., RAMSEY D. S., REMP D. G., SIMPSON W. L. The use of chicken antiserum for the rapid determination of plasma protein components. I. The assay of human serum albumin and gamma globulin. J Lab Clin Med. 1957 Jan;49(1):151–164. [PubMed] [Google Scholar]
- BERGLUND K. Hemolysin response in the rat after a single intraperitoneal injection of sheep erythrocytes. Acta Pathol Microbiol Scand. 1956;38(3):220–230. doi: 10.1111/j.1699-0463.1956.tb03170.x. [DOI] [PubMed] [Google Scholar]
- BERGLUND K. Studies on factors which condition the effect of cortisone on antibody production. 3. The significance of time of hormone administration in primary agglutinin response to S. typhi H. Acta Pathol Microbiol Scand. 1956;38(5):403–415. doi: 10.1111/j.1699-0463.1956.tb04660.x. [DOI] [PubMed] [Google Scholar]
- GUSTAFSSON B. E., LAURELL C. B. G Gamma globulins in germ-free rats. J Exp Med. 1958 Aug 1;108(2):251–258. doi: 10.1084/jem.108.2.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GUSTAFSSON B. E. Lightweight stainless steel systems for rearing germfree animals. Ann N Y Acad Sci. 1959 May 8;78:17–28. doi: 10.1111/j.1749-6632.1959.tb53092.x. [DOI] [PubMed] [Google Scholar]
- SCHEIDEGGER J. J. Une micro-méthode de l'immuno-electrophorèse. Int Arch Allergy Appl Immunol. 1955;7(2):103–110. [PubMed] [Google Scholar]
- THORBECKE G. J., GORDON H. A., WOSTMAN B., WAGNER M., REYNIERS J. A. Lymphoid tissue and serum gamma globulin in young germfree chickens. J Infect Dis. 1957 Nov-Dec;101(3):237–251. doi: 10.1093/infdis/101.3.237. [DOI] [PubMed] [Google Scholar]
- WOSTMANN B. S. Serum proteins in germfree vertebrates. Ann N Y Acad Sci. 1959 May 8;78:254–260. [PubMed] [Google Scholar]