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. 1998 Jun 1;141(5):1097–1105. doi: 10.1083/jcb.141.5.1097

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Immunofluorescence of 293T cells transfected with the 436, 771, 989, 1597, 1955, and 10366 constructs, each containing 15 glutamines. The transfected cells were treated with tamoxifen 36-40 h after transfection and mAb 2166 (red) or BKP1 (green) was used to detect huntingtin. The cells were counterstained with the DNA stain DAPI (blue) (the DAPI stain is not visible in the 1597-15 panel). Huntingtin containing 15 repeats does not form aggregates but can be localized in the nucleus depending on the protein size. Huntingtin is localized entirely in the nucleus in the 436 and 771 constructs in the cells shown. Bar: (436-15) 8.87 μm; (771-15) 11.98 μm; (989-15) 16.18 μm; (1597-15) 16.04 μm; (1955-15) 15.2 μm; (10366-15) 21.37 μm.