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. 1998 Jun 1;141(5):1267–1275. doi: 10.1083/jcb.141.5.1267

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Electrical coupling between Cx32 (−/−) acinar cell pairs. (A) When evaluated as a function of time, junctional conductance was found to be rapidly abolished by halothane in a reversible manner. The dashed line indicates the zero conductance value. (B) Current-voltage relationships of gap junctional currents measured at the onset (○) and end (•) of an 8-s voltage pulse protocol. This relationship was almost linear for both measurements, indicating a modest sensitivity of the gap junctions to transjunctional voltage. Similar observations were made in two other cell pairs. (C) Example of unitary gap junction channel activity recorded in a Cx32 (−/−) acinar cell pair that was monitored in the presence of halothane. Current transitions evoked during a 40 mV transjunctional potential correspond to unitary conductances of about 125–140 pS.