Table 1.
Effect of HGA and caspase inhibitors on biochemical data of serum and urine, and apoptosis of III and double-mutant mice
| Mice | n | AST, IU/liter | ALT, IU/liter | BUN, mg/dl | SA, nmol/mmol creatinine | Apoptosis of hepatocytes, % |
|---|---|---|---|---|---|---|
| HGA-untreated | ||||||
| III | 6 | 107.0 ± 40.5 | 43.7 ± 23.5 | 26.3 ± 3.7 | 65 | <1 |
| DM | 5 | 89.2 ± 11.5 | 28.8 ± 9.5 | 25.6 ± 2.2 | 150 | <1 |
| DM + YVAD | 1 | 142 | 48 | 39 | ND | <1 |
| HGA-treated | ||||||
| III | 7 | 115.9 ± 33.4 | 26.4 ± 4.2 | 20.4 ± 5.1 | 150 | <1 |
| DM | 7 | 2,509.9 ± 3,116.1 | 1,487.3 ± 2,691.0 | 75.86 ± 71.0 | 205,000 | 30–80 |
| DM + YVAD | 6 | 793.4 ± 467.4 | 505.6 ± 397.1 | 27.2 ± 10.5 | 14,300 | 2–4 |
| DM + DEVD | 2 | 539 | 126 | 23 | ND | <1 |
AST, aspartate aminotransferase; ALT, alanine aminotransferase; BUN, blood urea nitrogen; SA, succinylacetone in pooled urine; DM, double mutant; ND, not done.