Figure 1.

ALCAR reverses the age-associated decline in R123 fluorescence. Hepatocytes isolated from rats either supplemented with 1.5% (wt/vol) ALCAR for 1 mo or unsupplemented were incubated with R123 30 min before analysis by flow cytometry. Results show that ALCAR supplementation significantly reverses the age-associated decline in mitochondrial membrane potential and abolishes the appearance of mitochondrial heterogeneity with age. Shown is a fluorogram typical of that seen in at least six experiments.