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. 2007 Mar 19;204(3):511–524. doi: 10.1084/jem.20061252

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Copyright © 2007, The Rockefeller University Press

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Figure 3. — Haplotype structure of the Char9 congenic segment of AcB55. (A) The position of the B6-derived chromosome 10 segment (gray) of AcB55 is shown on the A/J chromosome 10 background (white). Microsatellite markers used in Char9 linkage mapping studies are identified along with their positions on the physical map (in megabases). SNP-based genotypes (spacing of ∼100 kB) for 11 inbred strains (identified on top) were obtained from the WTCTC SNP database. B6 alleles are gray, and the minor alleles are white. Inbred strains were segregated into P. chabaudi–susceptible (S) and –resistant (R) strains (*, DBA/1J is susceptible), and blocks of conserved haplotypes that segregated with susceptibility were noted. The region of the haplotype covering the Char9 congenic segment is outlined, and the minimal interval is indicated. The 11 genes mapping to this minimal interval are shown, with genes expressed in the spleen highlighted in black. (B) The level of mRNA expression of positional candidates Vnn3, Stx7, Ctgf, Enpp1, Crsp3, and Epb4.1l2 was determined in the spleen of 10 inbred mouse strains by quantitative RT-PCR. Strains carrying the A/J-like haplotype in this region are shown in white, and strains with the B6-like haplotype are shown in gray. Expression level is shown as a mean of three replicates and relative to B6 (B6 = 1) after normalization to Hprt. Error bars represent SEM. (C) Inbred strains of mice display two major haplotypes defined by SNPs in the Vnn3 gene that are associated with susceptibility (white) or resistance (gray) to infection with P. chabaudi (P.c.) susceptibility. Int, intronic; sil, silent/synonymous; MS, missense/nonsynonymous; NS, nonsense/premature STOP.