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. 2007 Mar 19;204(3):667–680. doi: 10.1084/jem.20061287

Figure 2.

Figure 2.

Direct ex vivo correlation between NK cell TRAIL expression and liver inflammation in CHB patients. (a) Representative flow cytometry dot plot from a CHB patient stained with mAb to CD3, CD56, and TRAIL, and gated on CD3− cells. The percentages denote the proportion of freshly isolated CD3−CD56+ NK cells staining with TRAIL. (b) Top: PBMCs from patients with eAg-CHB were stained ex vivo, and the percentage of NK (CD3−CD56+) -expressing TRAIL upon flow cytometry was correlated with ALT. CD69+ NK cells are presented as a percent of total lymphocytes. Bottom: The percent of CD56bright NK cells out of total CD3−CD56+ NK cells and the percent of those CD56bright NK cells that were TRAIL+ was plotted against ALT. (c) Cross-sectional analysis of ex vivo surface TRAIL expression on CD3−CD56+ NK cells from healthy donors, HBV patients with low ALT (ALT < 60 IU/l for the last year), and HBV patients with raised ALT (ALT > 60 IU/L at time of sampling). Significance testing was performed using the Mann-Whitney U test.